Search results for "cellular biophysics"

showing 5 items of 5 documents

An insect brain computational model inspired by Drosophila melanogaster: architecture description

2010

The fruit fly Drosophila melanogaster is an extremely interesting insect because it shows a wealth of complex behaviors, despite its small brain. Nowadays genetic techniques allow to knock out the function of defined parts or genes in the Drosophila brain. Together with specific mutants which show similar defects in those parts or genes, hypothesis about the functions of every single brain part can be drawn. Following these experiments, a computational model of the fly Drosophila has been designed with a view to its robotic implementation.

biologymedia_common.quotation_subjectfungiSmall brainBrain PartComputational biologyInsectbiology.organism_classificationDrosophila melanogasterDrosophilaSoftware architecture descriptionFunction (biology)Cellular biophysicsmedia_common
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Automated approach for indirect immunofluorescence images classification based on unsupervised clustering method

2018

Autoimmune diseases (ADs) are a collection of many complex disorders of unknown aetiology resulting in immune responses to self-antigens and are thought to result from interactions between genetic and environmental factors. ADs collectively are amongst the most prevalent diseases in the U.S., affecting at least 7% of the population. The diagnosis of ADs is very complex, the standard screening methods provides seeking and recognizing of Antinuclear Antibodies (ANA) by Indirect ImmunoFluorescence (IIF) based on HEp-2 cells. In this paper an automatic system able to identify and classify the Centromere pattern is presented. The method is based on the grouping of centromeres present on the cell…

medical disorderComputer sciencePopulationFeature extraction02 engineering and technologybiomedical optical imagingmedical image processing030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineImage textureblood0202 electrical engineering electronic engineering information engineeringSegmentationimage texturecellular biophysicsCluster analysiseducationimage segmentationdiseaseeducation.field_of_studyIndirect immunofluorescenceContextual image classificationbusiness.industryfeature extractionPattern recognitionImage segmentationSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)020201 artificial intelligence & image processingfluorescenceComputer Vision and Pattern RecognitionArtificial intelligencebusinessSoftwareimage classificationIET Computer Vision
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Comparison of complex fractionated atrial electrograms at cellular scale using numerical and experimental models.

2010

This study investigates the existence of the pseudo complex fractionated atrial electrogram (CFAE) at cellular level. Our assumptions are based on the fact that CFAEs are linked to the generation of the spiral waves. These are created using a numerical model and an experimental model of in vitro culture of neonatal rats cardiac cells. Pseudo bipolar electrograms resulting from these two models are compared qualitatively and some patterns could be identified as CFAE signature.

PhysicsScale (ratio)Experimental modelModels CardiovascularAction PotentialsNumerical modelsCellular levelElectrocardiographyBiological ClocksHeart Conduction SystemAtrial FibrillationAnimalsHumansComputer SimulationMyocytes CardiacHeart AtriaBiological systemCellular biophysicsBiomedical engineeringAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
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A qualitative model of the HIV vital cycle

1992

Qualitative modelling is a recent artificial intelligence approach to physical system modelling. This approach has been successfully applied in several fields. On the basis of an analysis and qualitative modelling of cell growth, we reckon that a qualitative model of the vital cycle of HIV can be proposed, including the phases in which HIV can be attacked. The actions of antiviral drugs can also be qualitatively modelled, provided their action mechanism is known, even only in a broad sense.

Action (philosophy)Management scienceMechanism (biology)fungiImmunologyHuman immunodeficiency virus (HIV)medicinePhysical systemfood and beveragesBiologymedicine.disease_causeCellular biophysics
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Texture analysis and optical anisotropy measurements of leukocytes for early diagnostics of diabetes mellitus

2004

DNA damage had been suggested to contribute to the pathogenesis of insulin dependent diabetes mellitus (IDDM). In this work we present a method for detection and discrimination of such DNA changes by means of analysis of light microscope images of anisotropically stained leukocytes nuclei. Several features of the images have been evaluated, including integrated optical density, degree of polarisation, and textural features. A genetic algorithm, coupled with a neural classifier, has been used to find the best features for identification of the pathology. Reported results indicate the best set is able to achieve an 83% correct classification ratio.

Materials scienceOptical anisotropybusiness.industryDNA damagePattern recognitionOptical densitymedicine.diseasePatient diagnosisImage textureDiabetes mellitusInsulin dependent diabetesmedicineComputer visionArtificial intelligencebusinessCellular biophysicsProceedings 2003 International Conference on Image Processing (Cat. No.03CH37429)
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